Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana.
Identifieur interne : 000236 ( Main/Exploration ); précédent : 000235; suivant : 000237Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana.
Auteurs : Christian Obirikorang [Ghana] ; Razak Gyesi Issahaku [Ghana] ; Derick Nii Mensah Osakunor [Ghana] ; James Osei-Yeboah [Ghana]Source :
- AIDS research and treatment [ 2090-1240 ] ; 2016.
Abstract
Aim. We determined the prevalence of anaemia and evaluated markers of iron homeostasis in a cohort of HIV patients. Methods. A comparative cross-sectional study on 319 participants was carried out at the Tamale Teaching Hospital from July 2013 to December 2013, 219 patients on HAART (designated On-HAART) and 100 HAART-naive patients. Data gathered include sociodemography, clinical history, and selected laboratory assays. Results. Prevalence of anaemia was 23.8%. On-HAART participants had higher CD4/CD3 lymphocyte counts, Hb, HCT/PCV, MCV, MCH, iron, ferritin, and TSAT (P < 0.05). Hb, iron, ferritin, and TSAT decreased from grade 1 to grade 3 anaemia and CD4/CD3 lymphocyte count was lowest in grade 3 anaemia (P < 0.05). Iron (P = 0.0072) decreased with disease severity whilst transferrin (P = 0.0143) and TIBC (P = 0.0143) increased with disease severity. Seventy-six (23.8%) participants fulfilled the criteria for anaemia, 86 (26.9%) for iron deficiency, 41 (12.8%) for iron deficiency anaemia, and 17 (5.3%) for iron overload. The frequency of anaemia was higher amongst participants not on HAART (OR 2.6 for grade 1 anaemia; OR 3.0 for grade 3 anaemia). Conclusion. In this study population, HIV-associated anaemia is common and is related to HAART status and disease progression. HIV itself is the most important cause of anaemia and treatment of HIV should be a priority compared to iron supplementation.
DOI: 10.1155/2016/1623094
PubMed: 27092270
Affiliations:
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Medical Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Medical Laboratory Department, Tamale Teaching Hospital, Tamale</wicri:regionArea><wicri:noRegion>Tamale</wicri:noRegion></affiliation></author><author><name sortKey="Osakunor, Derick Nii Mensah" sort="Osakunor, Derick Nii Mensah" uniqKey="Osakunor D" first="Derick Nii Mensah" last="Osakunor">Derick Nii Mensah Osakunor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Osei Yeboah, James" sort="Osei Yeboah, James" uniqKey="Osei Yeboah J" first="James" last="Osei-Yeboah">James Osei-Yeboah</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Laboratory Sciences, University of Health and Allied Sciences, Ho, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Medical Laboratory Sciences, University of Health and Allied Sciences, Ho</wicri:regionArea><wicri:noRegion>Ho</wicri:noRegion></affiliation></author></analytic><series><title level="j">AIDS research and treatment</title><idno type="ISSN">2090-1240</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aim. We determined the prevalence of anaemia and evaluated markers of iron homeostasis in a cohort of HIV patients. Methods. A comparative cross-sectional study on 319 participants was carried out at the Tamale Teaching Hospital from July 2013 to December 2013, 219 patients on HAART (designated On-HAART) and 100 HAART-naive patients. Data gathered include sociodemography, clinical history, and selected laboratory assays. Results. Prevalence of anaemia was 23.8%. On-HAART participants had higher CD4/CD3 lymphocyte counts, Hb, HCT/PCV, MCV, MCH, iron, ferritin, and TSAT (P < 0.05). Hb, iron, ferritin, and TSAT decreased from grade 1 to grade 3 anaemia and CD4/CD3 lymphocyte count was lowest in grade 3 anaemia (P < 0.05). Iron (P = 0.0072) decreased with disease severity whilst transferrin (P = 0.0143) and TIBC (P = 0.0143) increased with disease severity. Seventy-six (23.8%) participants fulfilled the criteria for anaemia, 86 (26.9%) for iron deficiency, 41 (12.8%) for iron deficiency anaemia, and 17 (5.3%) for iron overload. The frequency of anaemia was higher amongst participants not on HAART (OR 2.6 for grade 1 anaemia; OR 3.0 for grade 3 anaemia). Conclusion. In this study population, HIV-associated anaemia is common and is related to HAART status and disease progression. HIV itself is the most important cause of anaemia and treatment of HIV should be a priority compared to iron supplementation.</div></front></TEI><affiliations><list><country><li>Ghana</li></country></list><tree><country name="Ghana"><noRegion><name sortKey="Obirikorang, Christian" sort="Obirikorang, Christian" uniqKey="Obirikorang C" first="Christian" last="Obirikorang">Christian Obirikorang</name></noRegion><name sortKey="Issahaku, Razak Gyesi" sort="Issahaku, Razak Gyesi" uniqKey="Issahaku R" first="Razak Gyesi" last="Issahaku">Razak Gyesi Issahaku</name><name sortKey="Osakunor, Derick Nii Mensah" sort="Osakunor, Derick Nii Mensah" uniqKey="Osakunor D" first="Derick Nii Mensah" last="Osakunor">Derick Nii Mensah Osakunor</name><name sortKey="Osei Yeboah, James" sort="Osei Yeboah, James" uniqKey="Osei Yeboah J" first="James" last="Osei-Yeboah">James Osei-Yeboah</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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